- Blockade prevents trade with other sectors
  - Bounty hunters search for an infamous fugitive
  - Chaotic breaches in spacetime spread like wildfire
  - Criminal faction corrupts local authorities
  - Devastating superweapon has fallen into the wrong hands
  - Energy storms are rampant
  - Magnetic disturbances disrupt communication
  - Newly found resource lures greedy fortune hunters to the sector
  - Notorious pirate clan preys on starships
  - Parasitic lifeforms spread like a plague
  - Precursor sites throughout the sector emit strange signals
  - Prophecies foretell an imminent awakening of a dreadful power
  - Raider clan emerges as a dominant threat under a new leader
  - Religious zealots overrun the sector
  - Rogue AI infiltrates systems throughout the sector
  - Settlements or factions are on the brink of war
  - Ships regularly go missing
  - Sickness spreads among ships and settlements
  - Supernova is imminent
  - Titanic spaceborne lifeform stalks the spaceways